The relationship of osteopontin and related cytokin levels with disease activity, treatment and comorbidities in psoriasis vulgaris

作者：Bulur Isil^*; Gulekon Ayla; Erdem Ozlem; Yucel Aysegul Atak; Celik Sevinc; Aral Arzu

来源：Turkderm-Archives of the Turkish Dermatology and Venerology, 2013, 47(3): 142-147.

DOI：10.4274/turkderm.55798

• Psoriasis
• osteopontin
• cytokine

Background and Design: The IL23/Th17 axis is an exciting new pathway in the pathogenesis of psoriasis. Osteopontin (OPN) is a recently defined phosphorylated acidic glycoprotein which has an effect on psoriasis, especially over Th1/Th17 cells. We aimed to understand the role of OPN and Th1/Th17 pathway in the immunopathogenesis of psoriasis, to assess its relationship with disease severity and to introduce the potential target molecules for therapeutic intervention in psoriatic patients. Materials and %26lt;br%26gt;Methods: Our study included 34 psoriatic patients. Seventeen patients were treated with corticosteroid/calsiporiol in topical treatment group and 17 patients were treated with methotrexate in the systemic treatment group. OPN and TNF-alpha, IFN-g, IL-23, and IL-17 levels were evaluated in serum and skin samples. The results were compared between topical and systemic treatment groups, before and after treatment. %26lt;br%26gt;Results: There was no significant difference between the treatment groups in terms of pretreatment OPN, TNF-alpha, IFN-GAMA, IL-23, and IL-17 levels in serum and skin samples in psoriatic patients (p%26gt;0.05). There was no correlation of severity of psoriasis with serum cytokin levels and OPN. IFN-gamma and IL-17 levels were significantly decreased after treatment in both patient groups (p%26lt;0.05). OPN, TNF-alpha, and IL-23 levels did not change with treatment (p%26gt;0.025). The posttreatment serum OPN levels were statistically significantly decreased in systemic treatment group, whereas OPN levels were decreased in skin samples in topical treatment group after treatment. There was no statistically significant relationship of the increase in OPN, IFN-GAMA, IL-23, IL-17, and levels with the accompanied comorbidities. %26lt;br%26gt;Conclusion: All these results showed that IFN-gamma, TNF-alpha, IL-23, IL-17 and OPN levels increase both in lesion and serum in psoriasis patients, however, further investigation should be made in order to assess their role in the immunopathogenesis of psoriasis and their relationship with the disease and comorbidities.

• 出版日期2013-9