Vitamin D and aging: Beyond calcium and bone metabolism

作者：Perez Lopez Faustino R^*; Chedraui Peter; Fernandez Alonso Ana M

来源：Maturitas, 2011, 69(1): 27-36.

DOI：10.1016/j.maturitas.2011.02.014

• Aging
• Vitamin D
• Mortality
• Frailty
• Vitamin D polymorphisms
• 1,25-Dihydroxyvitamin D
• 25-Hydroxyvitamin D
• Vitamin D receptor

Background: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism.
Objective: To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed.
Methods: The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google.
Results: Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25[OH]D levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25[OH]D levels.
Conclusion: The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.

• 出版日期2011-5