摘要
Eight new lupane triterpenes, including 7 beta-cis-coumaroylbetulinic acid (1), 7 beta-trans-coumaroylbetulinic acid (2), 7 beta-cis-coumaroyl-3-epi-betulinic acid (3), 7 beta-trans-coumaroyl-3-epi-betulinic acid (4), 7 beta-cis-coumaroylbetulonic acid (5), 7 beta-trans-coumaroylbetulonic acid (6), 7 beta-hydroxybetulinaldehyde (7) and 28-norlup-20(29)-ene-3 alpha, 17 beta-diol (8), together with fifteen known compounds were isolated from the bioactive methanol extract of the stems of Perrottetia arisanensis. The structures of the new compounds were elucidated by spectroscopic and HR-ESI-MS analysis. All new compounds were evaluated for their cytotoxicity against six human cancer cell lines. Among them, lupane triterpene coumaroyl esters 1-6 showed moderate cytotoxicity with IC50 values ranging from 3.75 to 21.29 mu M. This is the first report for lupane triterpenes with a phenylpropane moiety substituted at C-7.
- 出版日期2009-6
- 单位中山大学