Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep

作者：Suo Decheng; Wang Ruiguo; Wang Peilong; Zhao Genlong; Fan Yufei; Fan Xia; Li Yang; Su Xiaoou^*

来源：Journal of Analytical Toxicology, 2017, 41(2): 146-152.

DOI：10.1093/jat/bkw121

• TANDEM MASS-SPECTROMETRY
• BETA-AGONISTS
• RACTOPAMINE RESIDUES
• CLENBUTEROL RESIDUES
• GAS-CHROMATOGRAPHY
• ILLEGAL USE
• BOVINE
• ANIMALS
• TISSUES
• CATTLE

The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel beta-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at < 15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment. High residue concentrations were present in hair as early as Day 24 (14.8 +/- 3.6 and 25.8 +/- 7.6 ng/g) and Day 21 (23.4 +/- 6.6 ng/g) for swine and sheep; these residues persisted until withdrawal on Days 14 and 21. Results showed high PEA accumulation in hair, thereby indicating the use of hair as a matrix in the control of PEA abuse in farm animals.

• 出版日期2017-3
• 单位中国农业科学院农业质量标准与检测技术研究所