[Tris(pyrazolyl)methane]ruthenium Complexes Capable of Inhibiting Cancer Cell Growth

作者：Walker Jesse M; McEwan Alexis; Pycko Roxanne; Tassotto Mary Lynn; Gottardo Christine; Th'ng John; Wang Ruiyao; Spivak Gregory J^*

来源：European Journal of Inorganic Chemistry, 2009, 2009(31): 4629-4633.

DOI：10.1002/ejic.200900766

• Ruthenium
• Tris(pyrazolyl)methane
• Half-sandwich complexes
• Antiproliferative assays
• Anticancer agents

The [tris (pyrazolyl)methane]ruthenium complexes [(kappa(3)-tpm) RuCl(solv)(2)]PF(6) [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(kappa(3)-tpm)RuCl(LL)]PF(6) [LL = kappa(2)-dppe, kappa(2)-dppp, kappa(2)-dppb, (PMePh(2))(2)] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.

• 出版日期2009-11