Neurometabolite levels in antipsychotic-naive/free patients with schizophrenia: A systematic review and meta-analysis of H-1-MRS studies

作者：Iwata Yusuke; Nakajima Shinichiro; Plitman Eric; Mihashi Yukiko; Caravaggio Fernando; Chung Jun Ku; Kim Julia; Gerretsen Philip; Mimura Masaru; Remington Gary; Graff Guerrero Ariel^*

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2018, 86: 340-352.

DOI：10.1016/j.pnpbp.2018.03.016

• Schizophrenia
• Proton magnetic resonance spectroscopy
• Untreated
• Antipsychotic-naive

Background: Studies using proton magnetic resonance spectroscopy (H-1-MRS) have reported altered neurometabolite levels in patients with schizophrenia. However, results are possibly confounded by the influence of antipsychotic (AP). Thus, this meta-analysis aimed to examine neurometabolite levels in AP-naive/free patients with schizophrenia.
Methods: A literature search was conducted using Embase, Medline, and PsycINFO to identify studies that compared neurometabolite levels in AP-naive/free patients with schizophrenia to healthy controls (HCs). Eight neurometabolites (glutamate, glutamine, glutamate + glutamine, N-acetylaspartate [NAA], choline, creatine, myo-inositol, and gamma-Aminobutyric acid [GABA]) and seven regions of interest (ROI; medial prefrontal cortex, dorsolateral prefrontal cortex, frontal white matter, occipital lobe, basal ganglia, hippocampus/medial temporal lobe, and thalamus) were examined.
Results: Twenty-one studies (N = 1281) were included in the analysis. The results showed lower thalamic NAA levels (3 studies, n = 174, effect size = -0.56, P = 0.0005) in the patient group. No group differences were identified for other neurometabolites.
Conclusions: Our findings suggest that impaired neuronal integrity in the thalamus may be a potential trait maker in the early stages of schizophrenia.

• 出版日期2018-8-30