Depression of whole-brain oxygen extraction fraction is associated with poor outcome in pediatric traumatic brain injury

作者：Ragan Dustin K; McKinstry Robert; Benzinger Tammie; Leonard Jeffrey; Pineda Jose A^*

来源：Pediatric Research, 2012, 71(2): 199-204.

DOI：10.1038/pr.2011.31

INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Metabolic failure is an integral component of the pathological aftermath of TBI. The oxygen extraction fraction (OEF) is a valuable parameter for characterization and description of metabolic abnormalities; however, OEF measurement has required either invasive procedures or the use of ionizing radiation, which significantly limits its use in pediatric research.
RESULTS: Patients with TBI had depressed OEF levels that correlated with the severity of injury. In addition, the OEF measured within 2 weeks of injury was predictive of patient outcome at 3 mo after injury. In pediatric TBI patients, low OEF-a marker of metabolic dysfunction-correlates with the severity of injury and outcome.
DISCUSSION: Our findings support previous literature on the role of metabolic dysfunction after TBI.
METHODS: Using a recently developed magnetic resonance (MR) technique for the measurement of oxygen saturation, we determined the whole-brain OEF in both pediatric TBI patients and in healthy controls. Injury and outcome were classified using pediatric versions of the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale-Extended (GOS-E), respectively.

• 出版日期2012-2