A rhodium-catalyzed tandem reaction of N-sulfonyl triazoles with indoles: access to indole-substituted indanones

作者：Yuan, Hao; Gong, Jianxian^*; Yang, Zhen^*

来源：Chemical communications, 2017, 53(65): 9089-9092.

DOI：10.1039/c7cc05139e

• STEREOSELECTIVE-SYNTHESIS
• ASYMMETRIC-SYNTHESIS
• NAZAROV CYCLIZATION
• ENANTIOSELECTIVE SYNTHESIS
• TRANSANNULATION
• DERIVATIVES
• ALKYNES
• HYDROACYLATION
• CYCLOADDITION
• INHIBITORS

An efficient strategy for the synthesis of structurally diverse indole-substituted indanones via a rhodium(II)-catalyzed tandem reaction of N-sulfonyltriazoles with indoles was developed. The reaction involves rhodium(II)-catalyzed denitrogenation of the N-sulfonyltriazoles to form an oxonium ylide, followed by nucleophilic addition of the indoles and subsequent skeletal rearrangement. This strategy provides straightforward access to indanone frameworks bearing quaternary carbon centers.

• 出版日期2017-8-21
• 单位北京大学; 北京大学深圳研究生院