A Signal-to-Cutoff Ratio in the Abbott Architect HIV Ag/Ab Combo Assay That Predicts Subsequent Confirmation of HIV-1 Infection in a Low-Prevalence Setting

作者：Jensen Tomas Ostergaard^*; Robertson Peter; Whybin Ross; Chambers Ian; Lahra Monica; Rawlinson William; Post Jeffrey John

来源：Journal of Clinical Microbiology, 2015, 53(5): 1709-1711.

DOI：10.1128/JCM.03583-14

A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.

• 出版日期2015-5