Anti-inflammatory Activity of Grains of Paradise (Aframomum melegueta Schum) Extract

作者：Ilic Nebojsa M^*; Dey Moul; Poulev Alexander A; Logendra Sithes; Kuhn Peter E; Raskin Ilya

来源：Journal of Agricultural and Food Chemistry, 2014, 62(43): 10452-10457.

DOI：10.1021/jf5026086

• anti-inflammatory
• grains of paradise
• aframomum melegueta Schum
• Zingiberaceae
• gingerols
• COX2
• paw edema

The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes.

• 出版日期2014-10-29