Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

作者：Heidari Farzad; Vasudevan Ramachandran^*; Ali Siti Zubaidah Mohd; Ismail Patimah; Etemad Ali; Pishva Seyyed Reza; Othman Fauziah; Abu Bakar Suhaili

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2015, 16(4): 872-879.

DOI：10.1177/1470320314538878

• Hypertension
• I
• D
• ACE
• polymorphism
• RAAS
• lisinopril
• enalapril

Introduction: Several studies show that the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with hypertension in various populations. The present study sought to determine the association of the I/D gene polymorphism among Malay male essential hypertensive subjects in response to ACE inhibitors (enalapril and lisinopril).
Materials and methods: A total of 72 patients with newly diagnosed hypertension and 72 healthy subjects were recruited in this study. Blood pressure was recorded from 0 to 24 weeks of treatment with enalapril or lisinopril. Genotyping of the I/D polymorphism was carried out using a standard PCR method.
Results: Statistically significant association of the D allele of the ACE gene was observed between the case and control subjects (p < 0.01). There was a decrease in blood pressure in the patients carrying the DD genotype (SBP=18.58.1 mmHg, DBP=15.29 +/- 7.1 mmHg) rather than the ID (SBP=4.1 +/- 3.3 mmHg, DBP=9.1 +/- 3.5 mmHg) and II genotypes (SBP= 3.0 +/- 0.2 mmHg, DBP 0.11 +/- 6.1 mmHg) of the ACE gene.
Conclusion: Patients carrying the DD genotype had higher blood pressure-lowering response when treated with ACE inhibitors enalapril or lisinopril than those carrying ID and II genotypes, suggesting that the D allele may be a possible genetic marker for essential hypertension among Malay male subjects.

• 出版日期2015-12