A novel flurophore-cyano-carboxylic-Ag microhybrid: Enhanced two photon absorption for two-photon photothermal therapy of HeLa cancer cells by targeting mitochondria

作者：Kong, Lin^*; Yang, Li; Xin, Chen-Qi; Zhu, Shu-Juan; Zhang, Hui-Hui; Zhang, Ming-Zhu; Yang, Jia-Xiang; Li, Lin; Zhou, Hong-Ping; Tian, Yu-Peng

来源：Biosensors and Bioelectronics, 2018, 108: 14-19.

DOI：10.1016/j.bios.2018.02.028

• Two-photon photothermal therapy
• Surface Plasmon resonance
• Organic-Ag microhybrid
• Enhanced two-photon absorption

In this study. a novel two-photon photothermal therapy (TP-PTT) agent based on an organic-metal microhybrid with surface Plasmon resonance (SPR) enhanced two-photon absorption (TPA) characteristic was designed and mthesized using a fluorescent cyano-carboxylic derivative 2-cyano-3-(9-ethyl-9H-carbazol-3-yl) -acrylic acid (abbreviated as CECZA) and silver nanoparticles through self-assembly process induced by the interfacial coordination interactions between the O/N atom of CECZA and Ag-+/- ion at the surface of Ag nanoparticles. The coordination interactions caused electron transfer from the Ag nanoparticles to CECZA molecules at the excited state, resulting in a decreased fluorescence quantum yield. The interfacial coordination interactions also en: hanced the nonlinear optical properties. including 13 times increase in the TPA cross-section (8). The decreased fluorescence auantum yield and increased two photon absorption caused by the SPR effect led excellent two: photon photothermal conversion. which was beneficial for the TP-PTT effect on HeLa cancer cells.

• 出版日期2018-6-15
• 单位安徽大学