Association of pre-transplant dialysis duration with outcome in kidney transplant recipients: a prevalent cohort study

作者：Remport Adam; Keszei Andras; Vamos Eszter Panna; Novak Marta; Jaray Jeno; Rosivall Laszlo; Mucsi Istvan; Molnar Miklos Zsolt^*

来源：International Urology and Nephrology, 2011, 43(1): 215-224.

DOI：10.1007/s11255-009-9700-4

• Chronic renal disease
• Dialysis duration
• Kidney transplantation
• Mortality
• Transplantation outcomes

Dialysis treatment prior to transplantation may contribute to premature mortality and graft loss in kidney-transplanted patients. In this prevalent cohort study (TransQol-HU Study), we analyzed the association between pre-transplant dialysis duration versus mortality and death-censored graft loss in kidney-transplanted patients.
Data from 926 kidney-transplanted patients followed at a single outpatient transplant center were analyzed. Socio-demographic parameters, laboratory data, medical history, donor characteristics and information on co-morbidities were collected at baseline. Data on 5-year outcome (graft loss, mortality) were collected.
In multivariate analyses, pre-transplant dialysis duration was an independent risk factor for mortality (HRfor each month increase = 1.011; 95% CI: 1.005-1.016) and also for death-censored graft loss (HRfor each month increase = 1.008; 95% CI: 1.001-1.015) after adjustment for several co-variables. In the multivariate model, patients with less than 1 year (HR = 0.498; 95% CI: 0.302-0.820; P = 0.006) and 1-3 years (HR = 0.577; 95% CI: 0.371-0.899; P = 0.015) of pre-transplant dialysis had significantly better survival after transplantation compared to those with more than 3 years on dialysis.
These findings add further strength to existing evidence about the significant association between longer pre-transplant dialysis duration and poor outcome in kidney-transplanted patients.

• 出版日期2011-3