A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer

作者：Yuan Qianying; Cai Shaoxin; Zhang Xuenong; Liu Ziwei; Li Zhaoming; Luo Xuelai; Xiong Chaomei; Wang Jianping; Hu Junbo^*; Ruan Jinlan

来源：Cancer Letters, 2012, 324(2): 210-220.

DOI：10.1016/j.canlet.2012.05.025

• RY10-4
• Breast cancer
• Anti-tumor
• PI3K/Akt

RY10-4, a novel protoapigenone analog, shows potent cytotoxicity against a broad spectrum of human cancer cells. Here we investigate its anti-tumor activity on breast cancer. The results indicated that RY10-4 suppressed proliferation, arrested cell cycle, induced apoptosis and inhibited invasion in MDA-MB-231, MCF-7 and SKBR3 breast cancer cells. Western blot analysis showed that RY10-4 down-regulated the PI3K/Akt signaling pathway and inhibited doxorubicin-induced p-Akt. Moreover, it effectively suppressed tumor growth in mice without major side effects. Therefore. RY10-4 had potential anti-tumor activity, and could be used as a lead to design more potent derivatives.

• 出版日期2012-11-28
• 单位华中科技大学