DOSE-RESPONSE EFFECT OF CHARGED CARBON BEAM ON NORMAL RAT RETINA ASSESSED BY ELECTRORETINOGRAPHY

作者：Mizota Atsushi^*; Tanaka Minoru; Kubota Mariko; Negishi Hisanari; Watanabe Emiko; Tsuji Hiroshi; Miyahara Nobuyuki; Furusawa Yoshiya

来源：International Journal of Radiation Oncology, Biology, Physics, 2010, 78(5): 1532-1540.

DOI：10.1016/j.ijrobp.2010.07.003

• Electroretinograms
• Retina
• Carbon beam
• Proton beam
• Radiation damage

Purpose To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats
Methods and Materials Eight week old Wister rats were used The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats
Results The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irra

• 出版日期2010-12-1