An on-site audit system for dosimetry credentialing of intensity-modulated radiotherapy in Japanese Clinical Oncology Group (JCOG) clinical trials

作者：Nakamura Mitsuhiro^*; Minemura Toshiyuki; Ishikura Satoshi; Nishio Teiji; Narita Yuichiro; Nishimura Yasumasa

来源：Physica Medica, 2016, 32(8): 987-991.

DOI：10.1016/j.ejmp.2016.07.002

• IMRT/VMAT
• Multi-institutional clinical trials
• On-site dosimetry credentialing

Purpose: This study was undertaken to analyze the results of intensity-modulated radiotherapy (IMRT) dosimetry credentialing using a phantom in the Japanese Clinical Oncology Group clinical trials.
Methods: All measurements were performed on-site. The IMRT phantom consisted of a phantom shell and a module. Two types of structures, including a C-shaped planning target volume (PTV) around a column-shaped organ at risk (OAR), were included in the module. Each participating institution was asked to image, plan, and treat the phantom. A prescription dose of 2 Gy should cover 95% of the PTV. The plan should limit the maximum doses to the PTV and OAR to less than 110% and 60%, respectively. The pass criteria were +/- 3% in terms of chamber dosimetry and a difference in profile position <= 2 mm in the high-dose gradient area of film dosimetry. The positional difference was defined as the largest distance between the measured and calculated positions at doses of 60% or 80%. These tolerances were based on the Japanese Society for Radiation Oncology IMRT guidelines.
Results: Credentialing was performed on a total of 44 treatment machines in 32 institutions from 2009 to 2015. All differences between measured and planned doses at the measurement points of the PTV were within 3%. The means +/- standard deviations of the positional differences were 1.0 +/- 0.4 mm and 0.9 +/- 0.3 mm without and with the phantom shell, respectively.
Conclusions: The dose differences and positional differences met the desired criteria in all institutions.

• 出版日期2016-8