Binding of a Dy(III) complex to apoferritin inhibits iron mineralization

作者：Xu, Zichen; Zhang, Lei^*; Li, Dongmei; Liu, Xiyun; Wang, Yuxia; Lin, Jianping

来源：Polyhedron, 2015, 92: 37-40.

DOI：10.1016/j.poly.2015.03.009

• Rare earth
• Apoferritin
• Bioinorganic chemistry
• Nanocomposite
• Iron mineralization

Apoferritin is a versatile platform for encapsulating a variety of materials, such as inorganic particles and metal complexes, in its nanocavity. However, loading apoferritin with rare earth metal complexes has been less studied, let alone investigating the binding effect of rare earth metal complexes on iron mineralization in apoferritin. In this work, a new cationic Dy(III) complex, [Dy(NO3)(H2O)(tmp)(2)](NO3)(2) (tmp = trimethylolpropane), was synthesized and subsequently loaded in apoferritin. The binding of the Dy(III) complex to apoferritin inhibited iron mineralization, a plausible explanation being that the early recognition of Fe2+ at the ferroxidase sites was disrupted as a result of the binding of the Dy(III) complex.

• 出版日期2015-5-28
• 单位南开大学