科研之友
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摘要
The inability to cure many diseases, such as cancer and arthritis, has stimulated the need for the development of new drugs from natural sources. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. As part of our search for new anti-inflammatory or anticancer potential drugs, organic fractions (chloroform, ethyl acetate and methanol) from the Mediterranean brown seaweed, Cystoseira compressa were evaluated for in vivo antiinflammatory activity, using the carrageenan-induced rat paw edema model and in vitro antiproliferative effect in three human cancer cell lines (A549, lung cell carcinoma; HCT15, colon cell carcinoma; and MCF7, breast adenocarcinoma), using an MTT assay. The chloroform and ethyl acetate fractions exhibited dose-dependent anti-inflammatory activity, comparable with the reference drug acetylsalicylic-lysine (300 mg/ kg; i. p.). The percent inhibition of edema, 3 h after carrageenan injection ranged from 63 to 76% and 65 to 78%, respectively. The organic fractions (F-CHCl3, F-EtOAC, and F-MeOH) also exhibited antiproliferative activity against the three human cancer cell lines with IC50 values ranging from 78-82 mg/ ml; 27-50 mg/ ml and 110-130 mg/ ml; respectively. Thus, the chloroform and ethyl acetate fractions of C. compressa evidenced an interesting anti-inflammatory activity associated with significant antiproliferative activity, efficacies that correlated with their total phenol content. The purification and the determination of chemical structures of compounds of these active fractions are under investigation. Drug Dev Res 73: 82-89, 2012.
- 出版日期2012-3
