Gold-Catalyzed 1,3-Addition of a Sp(3)-Hybridized C-H Bond to Alkenylcarbenoid Intermediate

作者：Bhunia Sabyasachi; Liu Rai Shung^*

来源：Journal of the American Chemical Society, 2008, 130(49): 16488-+.

DOI：10.1021/ja807384a

We report stereoselective synthesis of bicyclo[3.2.1]oct-6-en-2-ones through Au(l)-catalyzed cycloisomerization of an allenene-acetal functionality. This cyclization is mechanistically significant because it involves an unprecedented 1,3-addition of a Sp(3)-hybridized C-H bond to vinylcarbenoid moiety.

• 出版日期2008-12-10
• 单位清华大学