A domino amino-lactonisation of arylidene pyruvic acids (APAs) by amines in aqueous media

作者:Shiri Morteza*; Heravi Majid M; Soleymanifard Bita; Kruger Hendrik G; Zolfigol Mohammad Ali
来源:Tetrahedron, 2013, 69(15): 3257-3263.
DOI:10.1016/j.tet.2013.02.036

摘要

The aqueous reaction of arylidene pyruvic acids (APAs) with arylamines or urea under refluxing conditions leading to the formation of 3-(amino)-5-aryl-furan-2(5H)-one, without catalyst, is described. Also (E)-4-(4-chlorophenyl)-2-oxobut-3-enoic acid reacts with 1,2-phenylenediamine to form (E)-3-(4-chlorostyryl) quinoxalin-2(1H)-one under the same conditions. Excellent yields were observed after filtration of the product and washing with brine solution.

  • 出版日期2013-4-15