Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects

作者：Hayashi Tomonori^*; Morishita Yukari; Khattree Ravindra; Misumi Munechika; Sasaki Keiko; Hayashi Ikue; Yoshida Kengo; Kajimura Junko; Kyoizumi Seishi; Imai Kazue; Kusunoki Yoichiro; Nakachi Kei

来源：The FASEB Journal, 2012, 26(11): 4765-4773.

DOI：10.1096/fj.12-215228

• reactive oxygen species
• cytokines
• immunosenescence

Past exposure to atomic bomb (A-bomb) radiation has exerted various long-lasting deleterious effects on the health of survivors. Some of these effects are seen even after %26gt;60 yr. In this study, we evaluated the subclinical inflammatory status of 442 A-bomb survivors, in terms of 8 inflammation-related cytokines or markers, comprised of plasma levels of reactive oxygen species (ROS), interleukin (IL)-6, tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP), IL-4, IL-10, and immunoglobulins, and erythrocyte sedimentation rate (ESR). The effects of past radiation exposure and natural aging on these markers were individually assessed and compared. Next, to assess the biologically significant relationship between inflammation and radiation exposure or aging, which was masked by the interrelationship of those cytokines/markers, we used multivariate statistical analyses and evaluated the systemic markers of inflammation as scores being calculated by linear combinations of selected cytokines and markers. Our results indicate that a linear combination of ROS, IL-6, CRP, and ESR generated a score that was the most indicative of inflammation and revealed clear dependences on radiation dose and aging that were found to be statistically significant. The results suggest that collectively, radiation exposure, in conjunction with natural aging, may enhance the persistent inflammatory status of A-bomb survivors.-Hayashi, T., Morishita, Y., Khattree, R., Misumi, M., Sasaki, K., Hayashi, I., Yoshida, K., Kajimura, J., Kyoizumi, S., Imai, K., Kusunoki, Y., Nakachi, K. Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects. FASEB J. 26, 4765-4773 (2012). www.fasebj.org

• 出版日期2012-11