科研之友
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摘要
Our recently discovered, selective, on-resin route to N()-alkylated imidazolium-containing histidine residues affords new strategies for peptide mimetic design. In this, we demonstrate the use of this chemistry to prepare a series of macrocyclic phosphopeptides, in which imidazolium groups serve as ring-forming junctions. Interestingly, these cationic moieties subsequently serve to charge-mask the phosphoamino acid group that directed their formation. Neighbor-directed histidine N()-alkylation opens the door to new families of phosphopeptidomimetics for use in a range of chemical biology contexts.
- 出版日期2015-11
- 单位MIT; NIH
