Anti-insulin resistance effects of diarylheptanoids and flavonoids from Myrica rubra leaves

作者：Chen Pinghong; Yang Ching-Hsu; Yao Jeng-Yuan; Xia Jinmei; Zheng Weibing; Wu Xiuna; Li Jinming; Wang Yaying; Wang Guey-Horng; Xu Jianzhong; Luo Lianzhong; Chen Yung-Husan^*

来源：Minerva Biotecnologica, 2018, 30(1): 1-6.

DOI：10.23736/S1120-4826.17.02246-7

• Myrica
• Motor activity
• Diabetes mellitus, type 2
• Metabolic diseases

BACKGROUND: Some human metabolic enzymes, including AMPK, Acetyl-CoA carboxylase, E1 ubiquitin activating enzyme, glycogen synthase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are key indexes of metabolic disorders caused by type II diabetes. These enzymes are important for insulin regulation and stability maintenance of the human body.
METHODS: We analyzed the effects of (2R)-3',4"-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl) heptan-3-one (compound 1), myricanol (compound 2), myricetin (compound 3) and myricitrin (compound 4) extracted from Myrica rubra leaves on type II diabetes.
RESULTS: We discovered that 2R)-3',4"-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl) heptan-3-one (compound 1) was the best compound to relieve metabolic disorders caused by type II diabetes.
CONCLUSIONS: We concluded that the four compounds promoted glycogen synthesis and improved the overall effectiveness of carbohydrate metabolism.

• 出版日期2018-3
• 单位厦门医学院; 国家海洋局第三海洋研究所