Schistosoma mansoni: TGF-beta signaling pathways

作者：LoVerde Philip T^*; Osman Ahmed; Hinck Andrew

来源：Experimental Parasitology, 2007, 117(3): 304-317.

DOI：10.1016/j.exppara.2007.06.002

• ALKs, activin receptor-like kinases
• ActRIb, activin type Ib receptor
• GS region, alternating glycine and serine residues
• AMH, anti-Mullerian hormone
• BMPs, bone morphogenetic proteins
• Co-Smads, Common-Smads
• cDNA, complementary deoxyribonucleic acid
• CBP, CREB binding protein
• EGFR, epidermal growth factor receptor
• e2IF alpha, eukaryotic translation initiation factor 2 alpha subunit
• ERK, extracellular signal-regulated kinase
• FKBP, FK506-binding protein
• GCN5, general control nonderepressible-5 protein
• GPI, glycosylphosphatidylinositol
• GCP, gynecophoral canal protein
• GDFs, growth/differentiation factors
• HAT, historic acetyltransferase
• h, human
• I-Smads, inhibitory Smads
• IL-7, Interleukin-7
• LAP, latency associated protein
• LTBP, latent TGF-beta binding protein
• MH, Mad homology region
• MAPK, mitogen-activated protein kinase
• Sm, Schistosoma mansoni
• SARA, Smad anchor for receptor activation
• SmInACT, SmInhibin/activin-like molecule
• ECD, N-terminal extracellular domain
• R-Smads, receptor-regulated Smads
• RK, receptor kinase
• RT-PCR, reverse transcriptase polymerase chain reaction
• RNAi, RNA interference
• siRNA, short interfering RNA
• SIP, SmRK1-interacting protein
• TGF-beta, transforming growth factor beta
• T beta RI, TGF-b type I receptor
• T beta RII, TGF-b type II receptor
• beta-ig-h3, transforming growth factor beta-induced gene-human clone 3, Host-parasite interactions
• male-female interactions
• Schistactivin receptor-like kinasesosoma mansoni
• Smad
• TGF-beta

Schistosome parasites have co-evolved an intricate relationship with their human and snail hosts as well as a novel interplay between the adult male and female parasites. We review the role of the TGF-beta signaling pathway in parasite development, host-parasite interactions and male-female interactions. The data to date support Multiple roles for the TGF-beta signaling pathway throughout schistosome development, in particular, in the tegument which is at the interface with the host and between the male and female schistosome, development of vitelline cells in female worms whose genes and development are regulated by a stimulus from the male schistosome and embryogenesis of the egg. The human ligand TGF-beta 1 has been demonstrated to regulate the expression of a schistosome target gene that encodes a gynecophoric canal protein in the schistosome worm itself. Studies on signaling in schistosomes opens a new era for investigation of host-parasite and male-female interactions.

• 出版日期2007-11