A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors-1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

作者：Szymanski Pawel^*; Skibinski Robert; Liszka Malgorzata; Jargielo Izabela; Mikiciuk Olasik Elzbieta; Komsta Lukasz

来源：Central European Journal of Chemistry, 2013, 11(6): 927-934.

DOI：10.2478/s11532-013-0218-3

• Lipophilicity
• Calculated partition coefficients
• AChE inhibitors
• Tetrahydroacridine
• Cyclopenta[b]quinoline

The lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane - citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. R-M values for pure water were extrapolated from the linear SoczewiA"ski-Wachtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values.
The obtained results were compared with computationally calculated partition coefficients values (AlogPs, AClogP, AlogP, MlogP, KOWWIN, XlogP2, XlogP3) by PCA and significant differences between them were observed.

• 出版日期2013-6