Global transcriptome analysis of Borrelia burgdorferi during association with human neuroglial cells

作者：Livengood Jill A; Schmit Virginia L; Gilmore Robert D Jr^*

来源：Infection and Immunity, 2008, 76(1): 298-307.

DOI：10.1128/IAI.00866-07

As adherence and entry of a pathogen into a host cell are key components to an infection, identifying the molecular mechanisms responsible for cellular association will provide a better understanding of a microbe's pathogenesis. We previously established an in vitro model for Borrelia burgdorferi infection of human neuroglial cells. To expand on our earlier study, we performed B. burgdorferi whole-genome expression analysis following a 20-hour infection of human neuroglial cells to identify borrelial genes that were differentially regulated during host-cell association compared with cultured Borrelia in cell-free medium. This study identifies several regulated genes, the products of which may be important mediators of cellular pathogenesis.

• 出版日期2008-1