Clinic-pathological and immunohistochemical aspects of equids infected with rabies virus

作者：Pedroso Pedro M O; Colodel Edson M; Gomes Danilo C; Varaschin Mary S; Bezerra Junior Pedro S; Barbosa Jose D; Tokarnia Carlos H; Driemeier David^*

来源：Pesquisa Veterinaria Brasileira, 2010, 30(11): 909-914.

DOI：10.1590/S0100-736X2010001100002

• Rabies
• Lyssavirus
• equids
• immunohistochemistry

Pedroso P.M.O., Colodel E. M., Gomes D. C., Varaschin M. S., Bezerra Junior P. S., Barbosa J.D., Tokarnia C. H. & Driemeier D. 2010. [Clinic-pathological and immunohistochemical aspects of equids infected with rabies virus.] Aspectos clinico-patologicos e imuno-histoquimicos de equideos infectados pelo virus da raiva. Pesquisa Veterinaria Brasileira 30(11): 909-914. Setor de Patologia Veterinaria, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves 9090, Porto Alegre, RS 91540-000, Brazil. E-mail: [e-mail]
Thirteen horses and one mule from four regions of Brazil with clinical and histological diagnosis of rabies were analyzed. The clinical course lasted four days, with motor incoordination, paresis and paralysis of the legs, and decubitus. The main histopathological findings were lymphoplasmacytic meningoencephalitis and non-suppurative meningomyelitis associated with characteristic Negri bodies in 64.28% (9/14) cases, mainly in the cervical spinal cord and in Purkinje neurons of the cerebellum. In 55.55% (5/9), the animals examined were positive by for the fluorescent antibody test for rabies. All animals were positive in immunohistochemistry for rabies, whose immunolabeling were more evident in the temporal cortex, occipital cortex and cervical spinal cord. Immunohistochemistry procedure was essential to confirm all cases of rabies in the equids.

• 出版日期2010-11