Monitoring of solid-phase synthesis of 7-fluoro-2H-1,4-benzoxazine-3(4H)-ones via FTIR spectroscopy

作者：Huang Ming Zhi^*; Chen Wei Min; Huang Ke Long; Huang Lu; Yang Guang Fu

来源：Chemical Journal of Chinese Universities, 2006, 27(11): 2117-2119.

• combinatorial chemistry
• solid-phase organic synthesis
• infrared spectroscopy

The solid-phase synthesis of 7-fluoro-1,4-2H-benzoxazine 3 (4H)-ones on Wang resin via esterification, etherification, reduction, cyclization and cleavage reactions was studied, and the reaction conditions were optimized after analyzing the reaction kinetics according to the IR spectrum.

• 出版日期2006-11-10
• 单位湖南化工研究院有限公司; 华中师范大学; 中南大学