Decreased Levels of Serum Omentin-1 in Patients with Inflammatory Bowel Disease

作者：Yin, Jian^*; Hou, Peng; Wu, Zhiqiang; Nie, Yanxiao

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 118-122.

DOI：10.12659/msm.892081

• Adipokines
• Inflammation
• Inflammatory Bowel Diseases

Background: Inflammation is involved in the mechanism of inflammatory bowel disease (IBD). Omentin, a newly discovered adipokine, is thought to play an anti-inflammatory role. This study aimed to determine whether serum levels of omentin-1 are associated with the presence and disease activity of IBD.
Material/Methods: This study consisted of 192 patients with IBD: 100 with Crohn's disease [CD], 92 with ulcerative colitis [UC], and 104 healthy subjects. Serum levels of omentin-1 were measured using enzyme-linked immunosorbent assay (ELISA).
Results: Serum omentin-1 levels were significantly decreased in CD and UC patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum omentin-1 levels were inversely associated with the presence of CD and UC. Active CD and UC patients both had significantly decreased levels of serum omentin-1 compared with inactive CD and UC patients. In both CD and UC patients, serum omentin-1 levels were significantly associated with decreased levels of body mass index (BMI) and C-reactive protein (CRP).
Conclusions: Decreased serum omentin-1 levels could be considered as an independent predicting marker of the presence and disease activity of IBD.

• 出版日期2015-1-10
• 单位中国人民解放军总医院