An Azafluorenone Alkaloid and a Megastigmane from Unonopsis lindmanii (Annonaceae)

作者：Yoshida Nidia C^*; de Siqueira Joao M; Rodrigues Ricardo P; Correia Rodolfo P; Garcez Wahnir S

来源：Journal of the Brazilian Chemical Society, 2013, 24(4): 529-+.

• Unonopsis lindmanii
• Annonaceae
• alkaloids
• azafluorenone
• megastigmanes

O alcaloide azafluorenona 5,8-dimetoxi-7-hidroxi-1-metil-4-azafluoren-9-ona e o megastigmano (-)-(5R*, 6S*)-megastigman-3-ona-10,7-olidio foram isolados dos partes aereas de Unonopsis lindmanii (Annonaceae), juntamente com os compostos conhecidos (3S*, 5S*, 8R*)-3,5-di-hidroxi-megastigma-6,7-dien-9-ona grasshopper ketone), N-trans-feruloiltiramina,(-)-anonaina, (-)-asimilobina, liriodenina e (-)-siringaresinol. Este e o primeiro relato da presenca de megastigmanos em Annonaceae. As estruturas dos compostos foram elucidadas com base em dados espectroscopicos.
The azafluorenone alkaloid 5,8-dimethoxy-7-hydroxy-1-methyl-4-azafluoren-9-one and the megastigman (-)-(5R*, 6S*)-megastigman-3-one-10,7-olide were isolated from aerial parts of Unonopsis lindmanii (Annonaceae), along with the known compounds (3S*, 5S*, 8R*)-3,5-dihydroxymegastigma-6,7-dien-9-one (grasshopper ketone), N-trans-feruloyltyramine, (-)-anonaine, liriodenine and (-)-syringaresinol. This is the first description of the presence of megastigmanes in Annonaceae. The structures of the compounds were elucidated based on spectroscopic data.

• 出版日期2013-4