Activation of I kappa B kinase beta and NF-kappa B is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils

作者：Yanai Ayako; Maeda Shin^*; Shibata Wataru; Hikiba Yohko; Sakamoto Kei; Nakagawa Hayato; Ohmae Tomoya; Hirata Yoshihiro; Ogura Keiji; Muto Susumu; Itai Akiko; Omata Masao

来源：Infection and Immunity, 2008, 76(2): 781-787.

DOI：10.1128/IAI.01046-07

The Mongolian gerbil model of Helicobacter pylori infection resembles human gastritis. In this study, we investigated the role of NF-kappa B activation in H. pylori-infected gerbils. Activated macrophages were significantly increased in H. pylori-infected gastric mucosa and were identified as being important cells with potent activation of NF-kappa B, which plays an important part in producing proinflammatory cytokines. Macrophage depletion by the administration of clodronate resulted in milder inflammation in gerbils infected with H. pylori. In macrophages, the inhibition of I kappa B kinase beta (IKK beta), which is a critical kinase for NF-kappa B activation, resulted in lower proinflammatory cytokine expression caused by heat-killed H. pylori cells. Furthermore, treatment with IKK beta inhibitor resulted in milder inflammation in gerbils with H. pylori gastritis. Collectively, our data suggest that H. pylori-mediated gastric inflammation critically depends on the efficient recruitment and activation of macrophages, with sufficient NF-kappa B activation.

• 出版日期2008-2
• 单位河北医科大学