Assessment of dietary exposure to bisphenol A in the French population with a special focus on risk characterisation for pregnant French women

作者：Bemrah Nawel^*; Jean Julien; Riviere Gilles; Sanaa Moez; Leconte Stephane; Bachelot Morgane; Deceuninck Yoann; Le Bizec Bruno; Dauchy Xavier; Roudot Alain Claude; Camel Valerie; Grob Konrad; Feidt Cyril; Picard Hagen Nicole; Badot Pierre Marie; Foures Franck; Leblanc Jean Charles

来源：Food and Chemical Toxicology, 2014, 72: 90-97.

DOI：10.1016/j.fct.2014.07.005

• Bisphenol A
• Food contamination
• Dietary exposure
• Occurrence
• Risk characterisation

Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital media such as CD%26apos;s and DVD%26apos;s, sport equipment, food and beverage containers, medical equipment). Here, we demonstrate the ubiquitous presence of this contaminant in foods with a background level of contamination of less than 5 mu g/kg in 85% of the 1498 analysed samples. High levels of contamination (up to 400 mu g/kg) were found in some foods of animal origin. We used a probabilistic approach to calculate dietary exposure from French individual consumption data for infants under 36 months, children and adolescents from 3 to 17 years, adults over 18 years and pregnant women. The estimated average dietary exposure ranged from 0.12 to 0.14 mu g/kg body weight per day (bw/d) for infants, from 0.05 to 0.06 mu g/kg bw/d for children and adolescents, from 0.038 to 0.040 mu g/kg bw/d for adults and from 0.05 to 0.06 mu g/kg bw/d for pregnant women. The main sources of exposure were canned foods (50% of the total exposure), products of animal origin (20%) and 30% as a background level. Based on the toxicological values set by the French Agency for Food, Environmental and Occupational Health %26 Safety (ANSES) for pregnant women, the risk was non negligible. Thus, we simulated scenarios to study the influence of cans and/or food of animal origin on the BPA-related risk for this specific population.

• 出版日期2014-10