An efficient approach to homocoupling of terminal alkynes: Solvent-free synthesis of 1,3-diynes using catalytic Cu(II) and base

作者：Wang, Dong; Li, Jihui; Li, Na; Gao, Tingting; Hou, Sihua; Chen, Baohua^*

来源：Green Chemistry, 2010, 12(1): 45-48.

DOI：10.1039/b917448f

• COUPLING REACTION
• CHEMISTRY
• DIYNES

We report an environmentally friendly, efficient method for transforming terminal acetylenes into 1,3-diynes based on catalytic amounts of a Cu(II) salt and base under solvent-free conditions. The developed process conforms to the principles of 'green' chemistry and addresses the shortage of such methods for the synthesis of 1,3-diynes. The reaction is quite general and results in good yields. Interestingly, the system also allows the synthesis of unsymmetric 1,3-diynes by cross-coupling of two different terminal alkynes. Finally, the catalyst can also be recycled.

• 出版日期2010
• 单位兰州大学