A Review of Acetaminophen Poisoning

作者：Hodgman Michael J^*; Garrard Alexander R

来源：Critical Care Clinics, 2012, 28(4): 499-+.

DOI：10.1016/j.ccc.2012.07.006

• Acetaminophen poisoning
• Acetaminophen overdose
• N-acetylcysteine
• Hepatotoxicity
• Fulminant hepatic failure
• Liver transplant
• Paracetamol

Acetaminophen poisoning remains one of the more common drugs taken in overdose with potentially fatal consequences. Early recognition and prompt treatment with N-acetylcysteine can prevent hepatic injury. With acute overdose, the Rumack-Matthew nomogram is a useful tool to assess risk and guide management. Equally common to acute overdose is the repeated use of excessive amounts of acetaminophen. Simultaneous ingestion of several different acetaminophen-containing products may result in excessive dosage. These patients also benefit from N-acetylcysteine. Standard courses of N-acetylcysteine may need to be extended in patients with persistently elevated plasma concentrations of acetaminophen or with signs of hepatic injury.

• 出版日期2012-10