Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

作者：Zhang, Jinhua^*; Sun, Xudong; Wang, Jiemin; Zhang, Fuhua; Li, Xiaohua; Han, Jian^*

来源：PLos One, 2017, 12(4): e0175052.

DOI：10.1371/journal.pone.0175052

• INDUCED GASTRODUODENAL DISEASES
• CYTOKINE GENE POLYMORPHISMS
• GASTRIC-CANCER
• INTERLEUKIN-1 POLYMORPHISMS
• ATROPHIC GASTRITIS
• VIRULENCE FACTORS
• DUODENAL-ULCER
• INCREASED RISK
• POPULATION
• SUSCEPTIBILITY

The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02-1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00- 1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and HospitalBased subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

• 出版日期2017-4-6
• 单位甘肃省第二人民医院; 西北民族大学; 兰州大学