Evaluation of Mass-Forming Intrahepatic Cholangiocarcinoma with Viral Hepatitis

作者：Horino Kei; Beppu Toru; Komori Hiroyuki; Masuda Toshiro; Hayashi Hiromitsu; Okabe Hirohisa; Takamori Hiroshi; Baba Hideo^*

来源：Hepato-Gastroenterology, 2012, 59(116): 1217-1219.

DOI：10.5754/hge09739

• Liver neoplasm
• Cholangiocarcinoma
• Viral hepatitis

Background/Aims: The con-elation between the mass-forming type of intrahepatic cholangiocarcinoma (ICC) and the infection of the hepatitis B virus and hepatitis C virus are poorly understood. In this study, the clinical features of 34 patients with the mass-forming type ICC were reviewed to evaluate prognostic determinants. Methodology: Between January 1997 and December 2007, 34 patients underwent surgical resection for the mass-forming type of ICC in Kumamoto University Hospital. The significance of 14 clinicopathological factors consisting of age, gender, CA19-9 levels, CEA levels, size, intrahepatic metastases, portal vein invasion, bile duct invasion, histological differentiation, lymph node involvement, type B or C hepatitis, lymph node dissection, Sirius Red score of the tumor and platelet count in peripheral blood were analyzed, with regard to prognostic aspect. Results: Univariate analysis showed that significant risk factors for poor survival included age %26gt;= 65 years, CEA levels %26gt;= 1.6ng/mL and pathological lymph node involvement. Multivariate analysis revealed that age, CEA levels and lymph node involvement were independent and significant poor prognostic factors. Conclusions: It was concluded that age, CEA levels and lymph node involvement were significantly poor prognostic factors. However, the infection with type B or C hepatitis was not a prognostic factor of the mass forming type ICC.

• 出版日期2012-6