科研之友
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摘要
Background: Cohen%26apos;s hypothesis states that pulmonary dysfunction is the underlying unifying factor that leads to numerous health risks of inhaled toxicants. Objective: To test the idea postulated by Cohen. Methods: We compiled a retrospective cohort (n = 8024) composed of participants in eight population-based research and occupational studies conducted between 1977 and 1989. Smoking history, occupational exposures, health indicators, and demographic information were obtained by questionnaire. Pulmonary function was assessed by spirometry. Results: Cox proportional hazards models were utilized to test the Cohen%26apos;s hypothesis. Risk of developing cancer increased (hazard ratio, 1.31; 95% confidence interval, 1.02 to 1.67) if a subject had an obstructive pulmonary disease at baseline. Conclusion: Impaired lung function caused by environmental and occupational exposures is one of the risk factors for the incidence of cancer.
- 出版日期2012-12
