A Crucial Role of IL-17 and IFN-gamma during Acute Rejection of Peripheral Nerve Xenotransplantation in Mice

作者：Yu, Xin^*; Jiang, Yanfang; Lu, Lu; Gong, Xu; Sun, Xiguang; Xuan, Zhaopeng; Lu, Laijin

来源：PLos One, 2012, 7(3): e34419.

DOI：10.1371/journal.pone.0034419

• T-CELL RESPONSES
• TH17 CELLS
• ALLOGRAFT-REJECTION
• NEUROMA FORMATION
• PORCINE ISLETS
• EFFECTOR
• LINEAGE
• INFLAMMATION
• DIFFERENTIATION
• TRANSPLANTATION

Nerve injuries causing segmental loss require nerve grafting. However, autografts and allografts have limitations for clinical use. Peripheral nerve xenotransplantation has become an area of great interest in clinical surgery research as an alternative graft strategy. However, xenotransplant rejection is severe with cellular immunity, and Th1 cells play an important role in the process. To better understand the process of rejection, we used peripheral nerve xenografts from rats to mice and found that mononuclear cells expressing IFN-gamma and IL-17 infiltrated around the grafts, and IFN-gamma and IL-17 producing CD4+ and CD8+ T cells increased during the process of acute rejection. The changes of IL-4 level had no significant difference between xenotransplanted group and sham control group. The rejection of xenograft was significantly prevented after the treatment of IL-17 and IFN-gamma neutralizing antibodies. These data suggest that Th17 cells contribute to the acute rejection process of peripheral nerve xenotransplant in addition to Th1 cells.

• 出版日期2012-3-30
• 单位吉林大学