Association Between TPH2 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

作者：Park Tae Won; Park Young Hyun; Kwon Ho Jang; Lim Myung Ho^*

来源：Genetic Testing and Molecular Biomarkers, 2013, 17(4): 301-306.

DOI：10.1089/gtmb.2012.0376

Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is a familial disorder and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the TPH2 gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). ADHD symptoms were evaluated with Conners%26apos; Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for TPH2 polymorphism. Alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of TPH2 gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs11179027 (odd ratio [OR] = 2.12, 95% confidence interval [CI] = 1.13-3.97, p = 0.020) and rs1843809 (OR = 0.48, 95% CI = 0.24-0.97, p = 0.040) of alleles of TPH2, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that TPH2 might be related to ADHD symptoms.

• 出版日期2013-4