Dangerous liaisons: polyglutamine meets HMGB

作者:Todi Sokol V*; Paulson Henry L
来源:Nature Cell Biology, 2007, 9(4): 359-361.
DOI:10.1038/ncb0407-359

摘要

Nine inherited neurodegenerative disorders are caused by polyglutamine (polyQ) expansions in diverse proteins. A study now suggests that polyQ-mediated depletion of nonhistone chromatin proteins enhances genotoxic stress induced by the disease protein.

  • 出版日期2007-4