科研之友
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摘要
The association between body lead burden and kidney disease remains controversial. Fifty-five African-American end-stage renal disease (ESRD) cases and 53 age- and sex-matched African-American controls without known renal disease were recruited from Tulane University-affiliated dialysis clinics and out-patient clinics, respectively. Blood lead was measured via atomic absorption spectrophotometry and tibia lead (a measure of body lead) was measured via (109)Cd-based K shell X-ray fluorescence. Median blood lead levels were significantly higher among ESRD cases (6 mu g/dL) compared to their control counterparts (3 mu g/dL; P < 0.001). Although no participants had overt lead poisoning (blood lead >= 25 mu g/dL), seven cases but no controls had blood lead levels above 10 mu g/dL (P = 0.006). The median tibia lead level was 17 micrograms of lead per gram of bone mineral (mu g/g) and 13 mu g/g among ESRD cases and their control counterparts, respectively (P = 0.134). Four ESRD cases (7%), but no controls, had a tibia lead level above 40 mu g/g (P = 0.115) while a similar proportion of cases and controls had tibia lead between 20 and 39 mu g/g (33% and 32%, respectively; P = 0.726). After adjustment for potential confounders, the odds ratios of ESRD associated with a tibia lead >= 20 mu g/g and each four-fold higher tibia lead (e.g., 5-20 mu g/g) were 1.55 (95% CI: 0.55, 4.41) and 1.88 (95% CI: 0.53, 6.68), respectively. These findings support the need for prospective cohort studies of body lead burden and renal disease progression.
- 出版日期2007-7
