A prospective analysis of F-18-FDG PET/CT in patients with uveal melanoma: comparison between metabolic rate of glucose (MRglu) and standardized uptake value (SUV) and correlations with histopathological features

作者：Calcagni Maria Lucia^*; Mattoli Maria Vittoria; Blasi Maria Antonietta; Petrone Gianluigi; Sammarco Maria Grazia; Indovina Luca; Mule Antonino; Rufini Vittoria; Giordano Alessandro

来源：European Journal of Nuclear Medicine and Molecular Imaging, 2013, 40(11): 1682-1691.

DOI：10.1007/s00259-013-2488-6

• F-18-FDG PET/CT
• MRglu
• SUV
• Uveal melanoma
• Grading

To evaluate whether standardized uptake value (SUV) and/or metabolic rate of glucose (MRglu) are different among epithelioid, mixed, and spindle cell uveal melanomas, as well as between low and high risk melanomas; to correlate ultrasonographic data and metabolic parameters with histopathological features; and to assess the role of F-18-FDG PET/CT for evaluating prognosis. %26lt;br%26gt;Of 34 eligible patients prospectively enrolled with clinical suspicion of medium/large uveal melanoma, 26 (15 men, mean age 62.8 +/- 11.8 years) were evaluated. All patients underwent metastatic work-up, 3-D dynamic brain and whole-body F-18-FDG PET/CT, and surgery. %26lt;br%26gt;Of the 26 ocular lesions, 23 showed F-18-FDG uptake, with a sensitivity of 88 %. MRglu was significantly higher in the epithelioid cell melanomas than in the spindle cell melanomas, as well as in high-risk lesions than in low-risk lesions (p = 0.01, p = 0.02, respectively). SUV and MRglu were correlated with histopathological features while ultrasonographic data were not. %26lt;br%26gt;MRglu is useful for distinguishing the different cell types in uveal melanoma, as well as high-risk from low-risk lesions, while SUV is not. MRglu provides a more accurate evaluation of glucose consumption, whereas SUV provides only an estimation. In addition, the metabolic parameters correlate with histopathological features, well also reflecting cellular behaviour in ocular malignancy. A longer follow-up is needed to assess the role of F-18-FDG in evaluating prognosis.

• 出版日期2013-10