An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

作者：Zhu, Songlei^*; Wang, Jing; Xu, Zhou; Li, Jie

来源：Molecules, 2012, 17(12): 13856-13863.

DOI：10.3390/molecules171213856

• pyrano[3,2-c]quinolin-2,5(6H)-dione
• multi-component reaction
• L-proline

A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum's acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.

• 出版日期2012-12
• 单位徐州医科大学