Nanostructuration of titania films prepared by self-assembly to affect cell adhesion

作者：Bass John D; Belamie Emmanuel^*; Grosso David; Boissiere Cedric; Coradin Thibaud; Sanchez Clement

来源：Journal of Biomedical Materials Research Part A, 2010, 93A(1): 96-106.

DOI：10.1002/jbm.a.32477

• adhesion
• nanotopography
• titanium oxide
• sol-gel techniques
• self-assembly

Nanostructured and dense titania films prepared by evaporation-induced self-assembly (EISA) are shown to Possess tunable topographical nanoscale features on the order 2-12 run. Thermal treatment (calcination) induces a transition from amorphous titania to crystalline anatase that modifies the chemical and Structural properties of the surfaces via the migration of matter. For nanostructured films, the nanoporous network changes from organized ellipsoidal pores, similar to 4 nm x 2 nm, to a grid-like structure with pores on the order of 12 nm, whereas dense films show a slight roughening of the surface. Cells seeded on templated films show measurable, statistically significant differences in morphology compared with cells seeded on dense films. Moreover, although crystallization of templated films results in Surfaces that promote less well-spread cells with higher circularities, the opposite trend is observed for dense films. As such, these results represent a new method to tailor interfaces for biomaterial applications, using EISA to control material patterning on the nanoscale. This self-assembly based approach allows the patterning on size scales that are inaccessible by most traditional techniques while offering the added pontential to package and control the release of bioactive molecules.

• 出版日期2010-4