Amphiphilic chiral receptor as efficient chiral solvating agent for both lipophilic and hydrophilic carboxylic acids

作者：Luo Zengwei; Zhong Cheng; Wu Xiaojun; Fu Enqin^*

来源：Tetrahedron Letters, 2008, 49(21): 3385-3390.

DOI：10.1016/j.tetlet.2008.03.113

• chiral solvating agent
• chiral recognition
• high enantioselectivity
• amphiphilic receptor

Two amphiphilic chiral receptors 2a and 2b were designed and synthesized. Both are efficient chiral solvating agents for chiral carboxylic acids. In particular, 2a is an excellent CSA not only for lipophilic guests, but also for some hydrophilic guests. It is the first CSA for the direct determination of the enantiomeric composition of hydrophilic chiral hydroxylated acid in protic polar solvent.

• 出版日期2008-5-19
• 单位武汉大学