High expression of CD38, CD69, CD95 and CD154 biomarkers in cultured peripheral T lymphocytes correlates with an increased risk of acute rejection in liver allograft recipients

作者：Boix Francisco; Milian Olga; San Segundo David; Mancebo Esther; Rimola Antoni; Fabrega Emilio; Fortuna Virginia; Mrowiec Anna; Castro Panete Maria J; de la Pena Jesus; Llorente Santiago; Minguela Alfredo; Bolarin Jose M; Paz Artal Estela; Lopez Hoyos Marcos; Brunet Merce; Muro Manuel^*

来源：Immunobiology, 2016, 221(5): 595-603.

DOI：10.1016/j.imbio.2016.01.008

• Acute rejection
• Biomarkers
• Surface antigens
• Liver transplantation
• Immunosuppressive treatment

The mayor goal still outstanding into the solid organ transplantation field involves the search of surrogate biomarkers able to predict several clinical events, such as acute rejection (AR) or opportunistic infection. In the present multicenter study, a series of interesting surface antigens with important activator or inhibitory immune functions on cultured peripheral T cells were monitored in liver transplant recipients drawn at baseline and up to one year after transplantation. Sixty-four patients were included in the multicenter study during 3 years. Pre-and post-transplantation surface antigens levels displayed significant differences between AR and non acute rejection (NAR) groups, and, also this differential expression was used to construct a risk predictive model based on a composite panel of outcome biomarkers (CD38, CD69, CD95 and CD154). The model was able to stratify these patients at high risk of AR. These preliminary results could provide basic information to improve the immunosuppressive treatment and it might better help to predict AR episodes.

• 出版日期2016-5