Antisynthetase syndrome and lung carcinoma: A fortuitous association?

作者：Courties A; Lidove O^*; Maisonobe T; Rigolet A; Hermet A; Girard P; Ziza J M

来源：Revue de Medecine Interne, 2014, 35(4): 271-273.

DOI：10.1016/j.revmed.2013.04.012

• Anti-Ro-52 antibodies
• Antisynthetase syndrome
• Neoplasia

Introduction. - Dermatomyositis and polymyositis are sometimes associated with neoplasia. Conversely, a link between antisynthetase syndrome and neoplasia has not been clearly demonstrated.
Case report. - We report a 54-year-old smoker male patient who presented with an antisynthetase syndrome with anti-Jo1 and anti-Ro-52 antibodies. An adenocarcinoma of the lung was diagnosed at the same time.
Conclusion. - Two recent studies showed that patients with an antisynthetase syndrome associated with anti-Jol antibodies have more severe prognosis than antisynthetase syndrome associated with other antibodies (i.e. PL7/PL12). The risk of cancer occurrence seems to be increased when the anti-Jo1 antisynthetase syndrome is associated with anti-Ro-52 antibodies. To date, there is no demonstrated association between antisynthetase syndrome and neoplasia.

• 出版日期2014-4