ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population

作者：Sakagami Takuro^*; Jinnai Nobuyoshi; Nakajima Toshiaki; Sekigawa Takashi; Hasegawa Takashi; Suzuki Eiichi; Inoue Ituro; Gejyo Fumitake

来源：Journal of Human Genetics, 2007, 52(1): 66-72.

DOI：10.1007/s10038-006-0081-6

• ADAM33
• aspirin-intolerant asthma
• single nucleotide polymorphism
• association
• Japanese population

Multiple single nucleotide polymorphisms (SNPs) within ADAM33 have been reported to be associated with asthma and bronchial hyper-responsiveness in Caucasian populations. We examined whether these SNPs contribute to a predisposition to asthma, especially aspirin-intolerant asthma (AIA), in the Japanese population. Ten polymorphic sites (ST+4, ST+7, T1, T2, T+1, V-3, V-2, V-1, V4, V5) were genotyped in 102 AIA patients, 282 aspirin-tolerant asthma (ATA) patients and 120 control (CTR) subjects by direct sequencing. Haplotype frequencies were estimated by the expectation-maximization method. Differences in allele and haplotype frequencies among phenotypes were analyzed by the chi-square and permutation tests. ST+7, V-1 and V5 sites in the AIA group were significantly different from those in the ATA group (P=0.034-0.004) and from those in the CTR group (P=0.019-0.002). Haplotypes at three sites (ST+7, V-1, and V5) were significantly different in frequency between the AIA and ATA (P=0.008) or CTR (P=0.001) groups. Sequence variations in ADAM33 are likely to correlate with susceptibility to AIA in the Japanese population.

• 出版日期2007-1
• 单位河北医科大学