Urine HBV DNA: A New Aided Diagnostic Criterion for Hepatitis B Virus-Associated Glomerulonephritis

作者：Wang Lifen; Liang Huaban; Ye Zhiming; Zhang Bin; Xu Lixia; Feng Zhonglin; Liu Shuangxin; Shi Wei^*

来源：Journal of Biomaterials and Tissue Engineering, 2016, 6(4): 329-333.

DOI：10.1166/ibt.2016.1441

• Urine HBV DNA
• Hepatitis B Virus
• Glomerulonephritis
• HBV-GN

Objective: This study was conducted to investigate whether urine HBV DNA could be a new aided diagnostic criterion for HBV-GN. Methods: A total of 150 patients were enrolled in this study. The patients were divided into the following groups: HBV-GN (66 patients), non-HBV-GN (64 patients), and chronic hepatitis B (CHB) without renal disease (20 patients). Serum and urine HBV DNA were detected from all of the patients. Serum and urine HBV DNA levels were determined using polymerase chain reaction (PCR). Other serum HBV markers were detected using enzyme-linked immunosorbent assays. Results: In the diagnosis of HBV-GN, urine HBV DNA had a high specificity (0.98), a good positive predictive value (PPV, 0.95), and a modest negative predictive value (NPV, 0.58). Conclusions: Urine HBV DNA may be a new noninvasive aided diagnostic criterion for HBV directly infected renal tissues in HBV-GN.

• 出版日期2016-4
• 单位广东省人民医院