Fortifying the Link between SIRT1, Resveratrol, and Mitochondrial Function

作者：Denu John M^*

来源：Cell Metabolism, 2012, 15(5): 566-567.

DOI：10.1016/j.cmet.2012.04.016

The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. In this issue of Cell Metabolism, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).

• 出版日期2012-5-2